PAPPA anticorps (AA 351-523)

N° du produit ABIN7874250

L’anticorps anti-PAPPA Monoclonal Souris est utilisé pour la détection de PAPPA dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour PAPPA anticorps (AA 351-523) (ABIN7874250)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAPPA-2717

Détail du produit anti-PAPPA anticorps

Épitope: AA 351-523

Fonction: PAPPA Antibody / Pappalysin-1

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the PAPPA antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPPA

Sujet: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

UniProt: Q13219