PAPPA anticorps (AA 351-523)

N° du produit ABIN7874253

L’anticorps anti-PAPPA Monoclonal Souris est utilisé pour la détection de PAPPA dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour PAPPA anticorps (AA 351-523) (ABIN7874253)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IDIP-1

Détail du produit anti-PAPPA anticorps

Épitope: AA 351-523

Fonction: PAPPA Antibody / Pappalysin-1

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the PAPPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPPA

Sujet: The PAPPA gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [RefSeq]

UniProt: Q13219