Recombinant PAPPA anticorps (AA 351-523)

N° du produit ABIN7874255

Cet anticorps Lapin Monoclonal détecte spécifiquement PAPPA dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant PAPPA anticorps (AA 351-523) (ABIN7874255)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: PAPPA-8804R

Détail du produit anti-PAPPA anticorps

Épitope: AA 351-523

Fonction: Pappalysin-1 Antibody / PAPPA (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 351-523) from the human protein was used as the immunogen for the Pappalysin-1 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Pappalysin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Pappalysin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: Pappalysin-1

Sujet: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

UniProt: Q13219