SMAD7 anticorps (AA 353-388)

N° du produit ABIN7874259

L’anticorps anti-SMAD7 Polyclonal Lapin est utilisé pour la détection de SMAD7 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour SMAD7 anticorps (AA 353-388) (ABIN7874259)

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD7 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SMAD7 anticorps

Épitope: AA 353-388

Fonction: SMAD7 Antibody / MADH7

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids R353-Q388) was used as the immunogen for the SMAD7 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SMAD7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SMAD7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SMAD7

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Autre désignation: SMAD7

Sujet: Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization