TTLL9 anticorps (AA 36-439)

N° du produit ABIN7874319

L’anticorps anti-TTLL9 Polyclonal Lapin est utilisé pour la détection de TTLL9 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et WB.

Aperçu rapide pour TTLL9 anticorps (AA 36-439) (ABIN7874319)

Antigène: TTLL9 (Tubulin tyrosine Ligase-Like Family, Member 9 (TTLL9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTLL9 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-TTLL9 anticorps

Épitope: AA 36-439

Fonction: TTLL9 Antibody / Tubulin tyrosine ligase-like protein 9

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TTLL9 recombinant protein (Position: K36-S439) was used as the immunogen for the TTLL9 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TTLL9 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TTLL9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TTLL9

Antigène: TTLL9 (Tubulin tyrosine Ligase-Like Family, Member 9 (TTLL9))

Autre désignation: TTLL9

Sujet: TTLL9 antibody detects Tubulin tyrosine ligase-like protein 9, encoded by the TTLL9 gene. Tubulin tyrosine ligase-like protein 9 is a member of the tubulin tyrosine ligase-like family of enzymes and is involved in post-translational modification of tubulin through polyglutamylation. TTLL9 antibody provides researchers with a reagent for studying microtubule regulation, ciliary function, and neuronal biology.

Tubulin tyrosine ligase-like protein 9 belongs to a large family of enzymes that regulate tubulin side chain modifications. Research using TTLL9 antibody has shown that it catalyzes polyglutamylation of tubulin tails, a modification that regulates microtubule interactions with molecular motors and associated proteins. This modification is essential for the structural and functional diversity of the microtubule cytoskeleton.

Studies with TTLL9 antibody have demonstrated that polyglutamylation mediated by TTLL9 is critical for ciliary function and neuronal signaling. In cilia, TTLL9 activity regulates motility and sensory reception, while in neurons, it influences axonal transport and synaptic function. These findings underscore its broad importance in cellular physiology.

Dysfunction of Tubulin tyrosine ligase-like protein 9 has been linked to ciliopathies and neurological disease. Research using TTLL9 antibody has shown that defects in polyglutamylation cause impaired ciliary motility, sensory dysfunction, and neurodegeneration. In addition, altered TTLL9 activity has been observed in certain cancers, suggesting roles in proliferation and cytoskeletal regulation.

TTLL9 antibody is widely applied in immunofluorescence, western blotting, and immunohistochemistry. Immunofluorescence highlights modified microtubule arrays, western blotting quantifies expression across tissues, and immunohistochemistry demonstrates localization in brain and ciliated tissues. These applications make TTLL9 antibody indispensable in microtubule research.

By supplying validated TTLL9 antibody reagents, NSJ Bioreagents supports studies into tubulin modification, neuronal function, and ciliary biology. Detection of Tubulin tyrosine ligase-like protein 9 provides researchers with insight into how post-translational modification regulates microtubule diversity and disease.

UniProt: Q3SXZ7