SHE anticorps (AA 36-495)

N° du produit ABIN7874322

L’anticorps anti-SHE Polyclonal Lapin est utilisé pour la détection de SHE dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB, IHC, IF, FACS et ICC.

Aperçu rapide pour SHE anticorps (AA 36-495) (ABIN7874322)

Antigène: SHE (Src Homology 2 Domain Containing E (SHE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHE est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Détail du produit anti-SHE anticorps

Épitope: AA 36-495

Fonction: SHE Antibody / SH2 domain-containing adapter protein E

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SHE recombinant protein (Position: L36-H495) was used as the immunogen for the SHE antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SHE antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SHE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SHE

Antigène: SHE (Src Homology 2 Domain Containing E (SHE))

Autre désignation: SHE

Sujet: SHE antibody detects SH2 domain-containing adapter protein E, a cytoplasmic signaling adaptor that mediates growth factor and cytokine receptor signaling. Encoded by the SHE gene on chromosome 2p13.3, this protein functions downstream of receptor tyrosine kinases and cytokine receptors, facilitating the recruitment of effector molecules involved in cell growth, differentiation, and survival. By coupling phosphorylated receptors to intracellular signaling cascades, SHE helps coordinate pathways such as MAPK/ERK and PI3K/AKT.

SHE contains a central SH2 domain that binds phosphotyrosine motifs on activated receptors and associated kinases. Through its modular architecture, it acts as a scaffold that brings kinases and transcriptional regulators into close proximity, ensuring precise and timely propagation of receptor-initiated signals. SHE interacts with proteins such as EGFR, JAK2, and STAT3, influencing processes from hematopoietic differentiation to epithelial cell proliferation.

The SHE antibody is widely used in cell signaling, oncology, and hematology research to study adaptor-mediated signal transduction and receptor dynamics. Western blot analysis identifies a 62 kilodalton band corresponding to SHE, while immunofluorescence shows cytoplasmic and perinuclear localization in stimulated cells. This antibody is essential for dissecting receptor coupling events and understanding how adaptor proteins coordinate cellular responses to growth factors.

In cancer and immune regulation, altered SHE expression or phosphorylation disrupts normal signal transduction, leading to abnormal cell proliferation and survival. Overactivation of SHE-associated signaling contributes to tumor progression, while its suppression can impair cytokine responsiveness and differentiation. The SHE antibody provides a sensitive tool for evaluating these effects and monitoring adaptor function in normal and disease contexts. NSJ Bioreagents validates this antibody for its applications, ensuring dependable and reproducible performance for studies on receptor and kinase signaling networks.

UniProt: Q5VZ18