Factor VII anticorps (AA 366-466)

N° du produit ABIN7874349

L’anticorps anti-Factor VII Monoclonal Souris est utilisé pour la détection de Factor VII dans des échantillons de Humain. Il a été validé pour ELISA et IHC (p).

Aperçu rapide pour Factor VII anticorps (AA 366-466) (ABIN7874349)

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Factor VII est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: F7-3618

Détail du produit anti-Factor VII anticorps

Épitope: AA 366-466

Fonction: Factor VII Antibody

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 366-466 from the human protein was used as the immunogen for the Factor VII antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Factor VII antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Factor VII antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Factor VII

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Autre désignation: Factor VII

Sujet: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling