Factor VII anticorps (AA 366-466)

N° du produit ABIN7874361

L’anticorps anti-Factor VII Monoclonal Souris est utilisé pour la détection de Factor VII dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Factor VII anticorps (AA 366-466) (ABIN7874361)

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Factor VII est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: F7-4931

Détail du produit anti-Factor VII anticorps

Épitope: AA 366-466

Fonction: Coagulation Factor VII Antibody / F7

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the Coagulation Factor VII antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the Coagulation Factor VII antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Coagulation Factor VII antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Factor VII

Antigène: Factor VII (F7) (Coagulation Factor VII (F7))

Autre désignation: Coagulation Factor VII

Sujet: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling