PI4KB anticorps (AA 375-671)

N° du produit ABIN7874462

Cet anticorps Lapin Polyclonal détecte spécifiquement PI4KB dans WB, ELISA, IHC (p) et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PI4KB anticorps (AA 375-671) (ABIN7874462)

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PI4KB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-PI4KB anticorps

Épitope: AA 375-671

Fonction: PI4KB Antibody / Phosphatidylinositol 4-kinase beta

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived human recombinant protein (amino acids D375-D671) was used as the immunogen for the PI4KB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PI4KB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PI4KB Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PI4KB

Antigène: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Autre désignation: PI4KB

Sujet: Phosphatidylinositol 4-kinase beta is an enzyme that in humans is encoded by the PI4KB gene. Inositol phospholipids have an important role in intracellular signaling in response to hormones, growth factors and neurotransmitters. Phosphatidylinositol 4-kinase phosphorylates phosphatidylinositol (PI) to phosphatidylinositol-4-phosphate (PIP). In a second step, PIP is further phosphorylated to phosphatidylinositol-4,5-bisphosphate (PIP2), and PIP2 is subsequently hydrolyzed by phospholipase C, producing the two intracellular second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI4K230, PI4K92 and PI4K55 are three PI4 kinase isoforms that have been characterized and classified according to their molecular weights of 230, 92 and 55 kD. Previously, PI4 kinases were classified into type II and III enzymes. All isoforms are located on distinct membranes and cellular compartments suggesting various tasks. PI4K230 is located at the endoplasmatic reticulum and outer membranes of mitochondria, PI4K92 at the Golgi apparatus and endoplasmatic reticulum, and PI4K55 at the plasma membrane and endosomes. PI4K230 is predominantly expressed in brain and moderately sensitive to wortmannin as well as specifically and irreversibly inhibited by cyclitol derivatives.

UniProt: Q9UBF8

Pathways: Inositol Metabolic Process