Desmoglein 3 anticorps (AA 379-491)

N° du produit ABIN7874483

Cet anticorps Souris Monoclonal détecte spécifiquement Desmoglein 3 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Desmoglein 3 anticorps (AA 379-491) (ABIN7874483)

Antigène: Desmoglein 3 (DSG3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DSG3-2838

Détail du produit anti-Desmoglein 3 anticorps

Épitope: AA 379-491

Fonction: Desmoglein 3 Antibody / DSG3

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 379-491) was used as the immunogen for the Desmoglein 3 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Desmoglein 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Desmoglein 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Desmoglein 3

Antigène: Desmoglein 3 (DSG3)

Autre désignation: Desmoglein 3

Sujet: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

UniProt: P32926