MARCH5 anticorps (AA 4-32)

N° du produit ABIN7874670

L’anticorps anti-MARCH5 Polyclonal Lapin est utilisé pour la détection de MARCH5 dans des échantillons de Humain et Souris. Il a été validé pour WB et IHC (p).

Aperçu rapide pour MARCH5 anticorps (AA 4-32) (ABIN7874670)

Antigène: MARCH5 (Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARCH5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MARCH5 anticorps

Épitope: AA 4-32

Fonction: MARCH5 Antibody / Membrane-associated RING finger protein 5

Immunogène: A portion of amino acids 4-32 from the human protein was used as the immunogen for this MARCH5 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MARCH5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MARCH5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MARCH5

Antigène: MARCH5 (Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5))

Autre désignation: MARCH5

Sujet: Membrane-associated RING finger protein 5 (MARCH5), also known as MARCHF5, is involved in cellular processes that are essential for maintaining the homeostasis and integrity of the cell. It possesses a RING finger domain that allows it to function as an E3 ubiquitin ligase, mediating the ubiquitination and subsequent degradation of specific target proteins. One of the key functions of MARCH5 is its role in regulating the turnover of mitochondrial proteins. Studies have shown that MARCH5 targets a variety of mitochondrial proteins for ubiquitination, leading to their degradation by the proteasome. This process helps to maintain the quality control of mitochondria and ensures the proper functioning of these vital organelles. Furthermore, MARCH5 has been implicated in various cellular processes, including apoptosis, autophagy, and immune response. By targeting specific proteins for degradation, MARCH5 can regulate the signaling pathways that govern these processes, influencing cell survival, proliferation, and immunity. MARCH5 has also been linked to the development of certain diseases, such as Parkinson's disease and cancer. Dysregulation of MARCH5 expression or activity has been observed in these conditions.

UniProt: Q9NX47