DBH anticorps (AA 40-545)

N° du produit ABIN7874705

Cet anticorps Lapin Polyclonal détecte spécifiquement DBH dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DBH anticorps (AA 40-545) (ABIN7874705)

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DBH est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DBH anticorps

Épitope: AA 40-545

Fonction: DBH Antibody / Dopamine beta Hydroxylase

Purification: Affinity purified

Immunogène: A human recombinant protein (amino acids S40-N545) was used as the immunogen for the DBH antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the DBH antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the DBH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur DBH

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Autre désignation: DBH

Sujet: Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

UniProt: P09172

Pathways: Carbohydrate Homeostasis