GBP1 anticorps (AA 400-592)

N° du produit ABIN7874732

Cet anticorps Souris Monoclonal détecte spécifiquement GBP1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GBP1 anticorps (AA 400-592) (ABIN7874732)

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GBP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GBP1-7618

Détail du produit anti-GBP1 anticorps

Épitope: AA 400-592

Fonction: GBP1 Antibody / Guanylate binding protein 1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the GBP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GBP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the GBP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GBP1

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Autre désignation: GBP1

Sujet: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin