Cathepsin B anticorps (AA 42-339)

N° du produit ABIN7874922

L’anticorps anti-Cathepsin B Polyclonal Lapin est utilisé pour la détection de Cathepsin B dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, FACS et IHC (p).

Aperçu rapide pour Cathepsin B anticorps (AA 42-339) (ABIN7874922)

Antigène: Cathepsin B (CTSB)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin B est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Cathepsin B anticorps

Épitope: AA 42-339

Fonction: CTSB Antibody / Cathepsin B

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids Q42-K339) was used as the immunogen for the CTSB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CTSB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the CTSB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Cathepsin B

Antigène: Cathepsin B (CTSB)

Autre désignation: CTSB

Sujet: Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. And this gene is mapped to chromosome 8p22. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades