STOML2 anticorps (AA 43-293)

N° du produit ABIN7874961

L’anticorps anti-STOML2 Polyclonal Lapin est utilisé pour la détection de STOML2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, ELISA, IP et FACS.

Aperçu rapide pour STOML2 anticorps (AA 43-293) (ABIN7874961)

Antigène: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STOML2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Détail du produit anti-STOML2 anticorps

Épitope: AA 43-293

Fonction: STOML2 Antibody / Stomatin-like protein 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human STOML2 recombinant protein (Position: Q43-S293) was used as the immunogen for the STOML2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STOML2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STOML2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur STOML2

Antigène: STOML2 (Stomatin (EPB72)-Like 2 (STOML2))

Autre désignation: STOML2

Sujet: STOML2 antibody detects Stomatin-like protein 2, encoded by the STOML2 gene. Stomatin-like protein 2 is a mitochondrial inner membrane protein involved in mitochondrial organization, respiratory chain activity, and apoptosis regulation. STOML2 antibody provides researchers with a specific reagent for studying mitochondrial function, metabolic regulation, and cell death pathways.

Stomatin-like protein 2 belongs to the stomatin family of membrane-associated proteins, which share a conserved stomatin domain. Research using STOML2 antibody has shown that it localizes to mitochondria, where it regulates the stability of respiratory chain complexes. By supporting the assembly of complex I and complex IV, STOML2 ensures efficient oxidative phosphorylation and ATP production.

Studies with STOML2 antibody have revealed that it also participates in apoptosis regulation. Overexpression of Stomatin-like protein 2 enhances resistance to apoptotic stimuli, while depletion sensitizes cells to cell death. This suggests that STOML2 balances mitochondrial function with survival pathways, making it an important regulator of cellular fate under stress conditions.

Dysregulation of STOML2 expression has been linked to cancer. Research using STOML2 antibody has demonstrated that elevated expression supports tumor cell survival, proliferation, and migration by maintaining mitochondrial energy metabolism. High STOML2 expression correlates with poor prognosis in several cancers, including breast and gastric cancer. These findings emphasize its potential as a biomarker and therapeutic target.

Stomatin-like protein 2 also contributes to immune function. Studies with STOML2 antibody have suggested that it regulates T cell activation and cytokine production by influencing mitochondrial metabolism. This highlights its role in integrating energy metabolism with immune responses, broadening its functional relevance.

STOML2 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies mitochondrial protein expression, immunohistochemistry demonstrates expression in tissues with high energy demand, and immunofluorescence highlights colocalization with mitochondrial markers. These applications make STOML2 antibody indispensable for mitochondrial research.

By providing validated STOML2 antibody reagents, NSJ Bioreagents supports studies into mitochondrial biology, metabolism, and cancer. Detection of Stomatin-like protein 2 provides researchers with insight into how mitochondrial proteins regulate bioenergetics and cell survival.

UniProt: Q9UJZ1

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2