Uromodulin anticorps (AA 43-618)

N° du produit ABIN7874973

L’anticorps anti-Uromodulin Polyclonal Lapin est utilisé pour la détection de Uromodulin dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC (p) et FACS.

Aperçu rapide pour Uromodulin anticorps (AA 43-618) (ABIN7874973)

Antigène: Uromodulin (UMOD)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Uromodulin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-Uromodulin anticorps

Épitope: AA 43-618

Fonction: Uromodulin Antibody / UMOD

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids E43-S618) was used as the immunogen for the Uromodulin antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Uromodulin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Uromodulin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Autre désignation: Uromodulin

Sujet: Uromodulin (UMOD), also known as Tamm-Horsfall protein (THP), is a glycoprotein that in humans is encoded by the UMOD gene. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

UniProt: P07911