GRM2 anticorps (AA 439-710)

N° du produit ABIN7875001

Cet anticorps anti-GRM2 Polyclonal Lapin (ABIN7875001) détecte spécifiquement GRM2 dans WB, ELISA, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour GRM2 anticorps (AA 439-710) (ABIN7875001)

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-GRM2 anticorps

Épitope: AA 439-710

Fonction: GRM2 Antibody / Metabotropic Glutamate Receptor 2

Purification: Affinity purified

Immunogène: A human recombinant protein (amino acids N439-A710) was used as the immunogen for the GRM2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GRM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GRM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GRM2

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Autre désignation: GRM2

Sujet: Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport