COX2 anticorps (AA 442-572)

N° du produit ABIN7875031

Cet anticorps anti-COX2 Monoclonal Souris (Clone COX2-2377) (ABIN7875031) détecte spécifiquement COX2 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour COX2 anticorps (AA 442-572) (ABIN7875031)

Antigène: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp COX2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: COX2-2377

Détail du produit anti-COX2 anticorps

Épitope: AA 442-572

Fonction: COX2 Antibody / PTGS2

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 442-572 was used as the immunogen for the COX2 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the COX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur COX2

Antigène: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Autre désignation: COX2

Sujet: Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (COX2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and COX2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. COX2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90 % of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.

UniProt: P35354

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation