SOX4 anticorps (AA 45-130)

N° du produit ABIN7875055

Cet anticorps anti-SOX4 Monoclonal Souris (Clone PCRP-SOX4-1D6) (ABIN7875055) détecte spécifiquement SOX4 dans WB, IHC (p), IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SOX4 anticorps (AA 45-130) (ABIN7875055)

Antigène: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-SOX4-1D6

Détail du produit anti-SOX4 anticorps

Épitope: AA 45-130

Fonction: SOX4 Antibody

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 45-130 was used as the immunogen for the SOX4 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the SOX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the SOX4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SOX4

Antigène: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Autre désignation: SOX4

Sujet: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

UniProt: Q06945