GIPC3 anticorps (AA 45-312)

N° du produit ABIN7875064

Cet anticorps anti-GIPC3 Polyclonal Lapin (ABIN7875064) détecte spécifiquement GIPC3 dans WB, ELISA, FACS, ICC et IF. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour GIPC3 anticorps (AA 45-312) (ABIN7875064)

Antigène: GIPC3 (GIPC PDZ Domain Containing Family, Member 3 (GIPC3))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GIPC3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-GIPC3 anticorps

Épitope: AA 45-312

Fonction: GIPC3 Antibody / PDZ domain-containing protein GIPC3 / C19orf64

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human GIPC3 recombinant protein (Position: H45-G312) was used as the immunogen for the GIPC3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GIPC3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GIPC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GIPC3

Antigène: GIPC3 (GIPC PDZ Domain Containing Family, Member 3 (GIPC3))

Autre désignation: GIPC3

Sujet: GIPC3 antibody detects PDZ domain-containing protein GIPC3, a cytoplasmic adaptor protein involved in vesicular trafficking, receptor signaling, and auditory hair cell function. GIPC3 belongs to the GIPC family of PDZ domain-containing proteins that interact with transmembrane receptors to regulate endocytosis and intracellular transport. The GIPC3 antibody is used to study sensory biology, intracellular signaling, and genetic hearing loss.

GIPC3 is encoded by the GIPC3 gene located on human chromosome 19p13.3. The protein is approximately 36 kilodaltons and contains a central PDZ domain that binds C-terminal motifs of target proteins, as well as N- and C-terminal regions that mediate dimerization and association with myosin VI. Through these interactions, GIPC3 organizes membrane trafficking complexes that control receptor recycling and vesicle transport along actin filaments.

The GIPC3 antibody detects a 36 kilodalton band by western blot and shows cytoplasmic punctate localization in sensory epithelial cells. In the cochlea, GIPC3 is essential for hair cell synapse formation and auditory neurotransmission. Mutations in GIPC3 cause hereditary nonsyndromic deafness (DFNB72) by disrupting vesicular transport between inner hair cells and spiral ganglion neurons, leading to progressive hearing loss.

Functionally, GIPC3 modulates receptor signaling pathways, including those mediated by TGF-beta and IGF1, by regulating receptor endocytosis and recycling. It also interacts with proteins such as APPL1 and neuropilin, influencing cell migration and survival signaling. In neurons, GIPC3 may participate in axonal transport and synaptic vesicle cycling.

Beyond the auditory system, altered expression of GIPC3 has been linked to tumor progression and metastasis through modulation of growth factor receptor trafficking. Its PDZ-mediated interactions are targets for potential therapeutic inhibition in cancer and neurodegenerative disease. NSJ Bioreagents provides a validated GIPC3 antibody optimized for its applications, supporting research into vesicular trafficking, receptor regulation, and auditory function.

UniProt: Q8TF64