APOA1BP anticorps (AA 46-288)

N° du produit ABIN7875118

Cet anticorps anti-APOA1BP Polyclonal Lapin (ABIN7875118) détecte spécifiquement APOA1BP dans WB, IHC, ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour APOA1BP anticorps (AA 46-288) (ABIN7875118)

Antigène: APOA1BP (Apolipoprotein A-I Binding Protein (APOA1BP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOA1BP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-APOA1BP anticorps

Épitope: AA 46-288

Fonction: NAXE Antibody / NAD(P)HX epimerase

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NAXE recombinant protein (Position: R46-Q288) was used as the immunogen for the NAXE antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NAXE antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NAXE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur APOA1BP

Antigène: APOA1BP (Apolipoprotein A-I Binding Protein (APOA1BP))

Autre désignation: NAXE

Sujet: The NAXE antibody targets NAD(P)HX epimerase, an enzyme encoded by the NAXE gene that catalyzes the interconversion of the R and S epimers of NADHX and NADPHX. These damaged forms of NADH and NADPH arise through hydration of nicotinamide cofactors under stress conditions. NAD(P)HX epimerase acts together with NAD(P)HX dehydratase to repair these inactive metabolites, maintaining cofactor homeostasis and protecting cells from metabolic imbalance. The NAXE antibody enables precise detection of this enzyme in studies of cofactor metabolism, mitochondrial function, and cellular stress response.

NAD(P)HX epimerase localizes to both the cytosol and mitochondria, reflecting its role in multiple redox compartments. It is essential for the NAD(P)HX repair system, which safeguards the integrity of cellular redox reactions by regenerating functional NADH and NADPH. The NAXE antibody allows researchers to analyze this protective mechanism, revealing how cells maintain coenzyme pools under conditions of heat, oxidative, or metabolic stress. Loss of NAXE function leads to accumulation of toxic NADHX derivatives, disrupting energy metabolism and enzymatic activity.

Mutations in the NAXE gene cause a rare neurometabolic disorder characterized by recurrent encephalopathy and neurodegeneration, particularly following febrile illness. The NAXE antibody supports mechanistic studies into this disease, helping identify tissue-specific expression and enzyme deficiency in patient-derived samples. Defective NAD(P)HX epimerase activity compromises mitochondrial respiration and redox balance, underscoring its essential role in cellular survival.

Beyond its role in repair metabolism, NAD(P)HX epimerase contributes to stress adaptation and antioxidant defense. It ensures a continuous supply of NAD(P)H required for reductive biosynthesis and detoxification pathways. The NAXE antibody supports quantitative analyses of enzyme regulation in models of oxidative stress, aging, and metabolic disorders. Dysregulation of NAD(P)HX repair enzymes has also been linked to impaired neuronal function and energy deficiency syndromes.

The NAXE antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, providing characteristic mitochondrial and cytosolic staining. NSJ Bioreagents provides this antibody with validated specificity and reproducibility for biochemistry, metabolism, and neuroscience research. By enabling accurate detection of NAD(P)HX epimerase, the NAXE antibody advances understanding of cofactor repair, mitochondrial redox regulation, and neuroprotective metabolic pathways.

UniProt: Q8NCW5