RNF34 anticorps (AA 46-372)

N° du produit ABIN7875119

Cet anticorps Lapin Polyclonal détecte spécifiquement RNF34 dans WB, ELISA, FACS, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour RNF34 anticorps (AA 46-372) (ABIN7875119)

Antigène: RNF34 (Ring Finger Protein 34 (RNF34))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF34 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RNF34 anticorps

Épitope: AA 46-372

Fonction: RNF34 Antibody / hRFI / CARP-1

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids E46-S372) was used as the immunogen for the RNF34 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the RNF34 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the RNF34 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur RNF34

Antigène: RNF34 (Ring Finger Protein 34 (RNF34))

Autre désignation: RNF34

Sujet: E3 ubiquitin-protein ligase RNF34, also called Human RING finger homologous to inhibitor of apoptosis protein (hRFI) and Caspases-8 and -10-associated RING finger protein 1 (CARP-1) is an enzyme that in humans is encoded by the RNF34 gene. The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: Q969K3