Recombinant AMH anticorps (AA 460-560)

N° du produit ABIN7875130

Cet anticorps anti-AMH Monoclonal Lapin (Clone AMH-6713R) (ABIN7875130) détecte spécifiquement AMH dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant AMH anticorps (AA 460-560) (ABIN7875130)

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp AMH est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AMH-6713R

Détail du produit anti-AMH anticorps

Épitope: AA 460-560

Fonction: Muellerian Inhibiting Factor Antibody / Anti-Muellerian Hormone

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 460-560 from the human protein was used as the immunogen for the Muellerian Inhibiting Factor antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Muellerian Inhibiting Factor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Muellerian Inhibiting Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur AMH

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Autre désignation: Muellerian Inhibiting Factor

Sujet: The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion