AMH anticorps (C-Term)

N° du produit ABIN7875131

Cet anticorps Souris Monoclonal détecte spécifiquement AMH dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour AMH anticorps (C-Term) (ABIN7875131)

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AMH est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: AMH-7354

Détail du produit anti-AMH anticorps

Épitope: AA 460-560, C-Term

Fonction: Anti Mullerian Hormone Antibody / AMH (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of the C-terminus of the human protein (within amino acids 460-560) was used as the immunogen for the Anti Mullerian Hormone antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Anti Mullerian Hormone antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Anti Mullerian Hormone antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur AMH

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Autre désignation: Anti Mullerian Hormone

Sujet: The transforming growth factor beta (TGF beta) superfamily is composed of numerous growth and differentiation factors, including TGF beta1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin Alpha, beta-A, beta-B and beta-C, Lefty and Nodal. Members of the TGF beta superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion