RASAL3 anticorps (AA 48-925)

N° du produit ABIN7875219

L’anticorps anti-RASAL3 Polyclonal Lapin est utilisé pour la détection de RASAL3 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC, ELISA et FACS.

Aperçu rapide pour RASAL3 anticorps (AA 48-925) (ABIN7875219)

Antigène: RASAL3 (RAS Protein Activator Like 3 (RASAL3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASAL3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-RASAL3 anticorps

Épitope: AA 48-925

Fonction: RASAL3 Antibody / Ras GTPase-activating-like protein 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human RASAL3 recombinant protein (Position: R48-Q925) was used as the immunogen for the RASAL3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the RASAL3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the RASAL3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur RASAL3

Antigène: RASAL3 (RAS Protein Activator Like 3 (RASAL3))

Autre désignation: RASAL3

Sujet: RASAL3 antibody detects Ras GTPase-activating-like protein 3, a Ras signaling regulator that acts as a negative modulator of Ras activity in immune cells. The UniProt recommended name is Ras GTPase-activating-like protein 3 (RASAL3). This protein converts active GTP-bound Ras into its inactive GDP-bound form, thereby controlling proliferation and activation signals in lymphocytes and other hematopoietic cells.

Functionally, RASAL3 antibody identifies a 944-amino-acid cytoplasmic protein containing C2 and RasGAP domains responsible for lipid membrane binding and GTPase activation. RASAL3 inhibits Ras-dependent pathways, including ERK/MAPK signaling, limiting excessive immune cell activation and promoting homeostasis. It acts downstream of receptor stimulation to fine-tune immune responses.

The RASAL3 gene is located on chromosome 19q13.3 and is highly expressed in natural killer cells, T cells, and macrophages. It serves as a negative feedback regulator of immune activation by controlling Ras signaling intensity following antigen or cytokine stimulation. In NK cells, RASAL3 influences cytotoxic granule release and antiviral responses.

Pathologically, dysregulation of RASAL3 contributes to immune dysfunction and inflammation. Loss of function enhances Ras activity, promoting lymphoproliferative and autoimmune phenotypes. In cancer, RASAL3 downregulation may facilitate tumor immune evasion by disturbing immune regulation. Research using RASAL3 antibody supports investigations into Ras pathway modulation, immune signaling, and oncogenic Ras control.

RASAL3 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect RasGAP proteins and Ras activity regulators. NSJ Bioreagents offers RASAL3 antibody reagents optimized for studies in immune signaling, GTPase biology, and cellular regulation.

Structurally, Ras GTPase-activating-like protein 3 contains an N-terminal C2 lipid-binding domain and a C-terminal catalytic GAP domain. This architecture enables membrane association and inactivation of Ras. This antibody facilitates research on RASAL3's inhibitory role in signal transduction and immune modulation.

UniProt: Q86YV0