NETO1 anticorps (AA 5-514)

N° du produit ABIN7875312

L’anticorps anti-NETO1 Polyclonal Lapin est utilisé pour la détection de NETO1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et WB.

Aperçu rapide pour NETO1 anticorps (AA 5-514) (ABIN7875312)

Antigène: NETO1 (Neuropilin (NRP) and Tolloid (TLL)-Like 1 (NETO1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NETO1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-NETO1 anticorps

Épitope: AA 5-514

Fonction: NETO1 Antibody / Neuropilin and tolloid-like protein 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NETO1 recombinant protein (Position: R5-R514) was used as the immunogen for the NETO1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NETO1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NETO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NETO1

Antigène: NETO1 (Neuropilin (NRP) and Tolloid (TLL)-Like 1 (NETO1))

Autre désignation: NETO1

Sujet: NETO1 antibody detects Neuropilin and tolloid-like protein 1, a neuronal transmembrane glycoprotein that modulates ionotropic glutamate receptor function and synaptic plasticity. NETO1 acts as an auxiliary subunit of kainate-type glutamate receptors (KARs), regulating receptor trafficking, channel gating, and synaptic localization. The NETO1 antibody is widely used in neurobiology and synaptic physiology to study excitatory neurotransmission and learning mechanisms.

NETO1 is encoded by the NETO1 gene located on human chromosome 18q22.1. The protein is approximately 533 amino acids long and contains two extracellular CUB domains, a low-density lipoprotein receptor-like domain, a single transmembrane helix, and a short cytoplasmic tail. NETO1 is predominantly expressed in the hippocampus, cortex, and cerebellum, where it localizes to postsynaptic membranes and interacts with KAR subunits such as GluK2 and GluK5.

The NETO1 antibody detects a 63 kilodalton protein by western blot and shows punctate synaptic staining in neurons. NETO1 enhances the stability and functional diversity of KARs by modulating desensitization kinetics and surface expression. It contributes to long-term potentiation and synaptic scaling, processes underlying memory and learning. Mice lacking NETO1 display deficits in synaptic plasticity and spatial learning, confirming its critical role in excitatory neurotransmission.

Beyond the brain, NETO1 may participate in developmental signaling and axonal growth. Dysregulation or mutation of NETO1 has been associated with autism spectrum disorder, schizophrenia, and cognitive impairment. By shaping receptor signaling and synaptic strength, NETO1 maintains proper excitatory balance within neural circuits.

As a neuron-specific regulatory subunit of kainate receptors, NETO1 is a key molecule for studying excitatory synaptic physiology and plasticity. NSJ Bioreagents provides a validated NETO1 antibody optimized for its applications, supporting research into neurotransmission, synaptic regulation, and neurological disorders.

UniProt: Q8TDF5

Pathways: Regulation of long-term Neuronal Synaptic Plasticity