AMPD1 anticorps (AA 5-747)

N° du produit ABIN7875316

Cet anticorps anti-AMPD1 Polyclonal Lapin (ABIN7875316) détecte spécifiquement AMPD1 dans ELISA, WB, IHC et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour AMPD1 anticorps (AA 5-747) (ABIN7875316)

Antigène: AMPD1 (Adenosine Monophosphate Deaminase 1 (AMPD1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMPD1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-AMPD1 anticorps

Épitope: AA 5-747

Fonction: AMPD1 Antibody / AMP deaminase 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human AMPD1 recombinant protein (Position: K5-E747) was used as the immunogen for the AMPD1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the AMPD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the AMPD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur AMPD1

Antigène: AMPD1 (Adenosine Monophosphate Deaminase 1 (AMPD1))

Autre désignation: AMPD1

Sujet: AMPD1 antibody detects Adenosine monophosphate deaminase 1, encoded by the AMPD1 gene. Adenosine monophosphate deaminase 1 is a skeletal muscle-specific enzyme of the purine nucleotide cycle, responsible for converting AMP to IMP. AMPD1 antibody provides researchers with a useful reagent for studying muscle metabolism, energy homeostasis, and exercise physiology.

Adenosine monophosphate deaminase 1 is highly expressed in skeletal muscle and plays a key role in energy regulation during periods of high metabolic demand. Research using AMPD1 antibody has shown that the enzyme supports ATP regeneration by facilitating nucleotide turnover. Its activity ensures maintenance of energy balance in contracting muscle fibers and contributes to endurance capacity.

Studies with AMPD1 antibody have revealed that genetic deficiency of AMPD1 is one of the most common enzymatic defects in human muscle. Mutations in AMPD1 result in myoadenylate deaminase deficiency, a condition characterized by exercise intolerance, fatigue, and muscle pain. These findings demonstrate the clinical significance of AMPD1 in skeletal muscle health.

Beyond muscle, Adenosine monophosphate deaminase 1 may play roles in purine metabolism affecting systemic energy balance. Research using AMPD1 antibody has shown that altered expression influences nucleotide pools and cellular signaling, with possible implications in metabolic disease and cardiovascular function. AMPD1 is also studied for its potential contribution to purine-related disorders and immune responses.

AMPD1 antibody is widely applied in enzyme assays, western blotting, and immunohistochemistry. Enzyme assays confirm catalytic activity in skeletal muscle biopsies, western blotting quantifies expression in normal and deficient tissues, and immunohistochemistry highlights distribution within muscle fibers. These applications make AMPD1 antibody essential in both basic and clinical research.

By supplying validated AMPD1 antibody reagents, NSJ Bioreagents supports studies into purine metabolism, muscle physiology, and metabolic disorders. Detection of Adenosine monophosphate deaminase 1 provides researchers with insight into how purine cycle enzymes regulate energy balance in skeletal muscle.

UniProt: P23109