SOX11 anticorps (AA 50-200)

N° du produit ABIN7875330

L’anticorps anti-SOX11 Monoclonal Souris est utilisé pour la détection de SOX11 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour SOX11 anticorps (AA 50-200) (ABIN7875330)

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX11 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SOX11-7236

Détail du produit anti-SOX11 anticorps

Épitope: AA 50-200

Fonction: SOX11 Antibody

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 50-200 was used as the immunogen for the SOX11 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the SOX11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SOX11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SOX11

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Autre désignation: SOX11

Sujet: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation