HBP1 anticorps (AA 51-506)

N° du produit ABIN7875522

L’anticorps anti-HBP1 Polyclonal Lapin est utilisé pour la détection de HBP1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et ELISA.

Aperçu rapide pour HBP1 anticorps (AA 51-506) (ABIN7875522)

Antigène: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HBP1 anticorps

Épitope: AA 51-506

Fonction: HBP1 Antibody / HMG-box transcription factor 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human HBP1 recombinant protein (Position: D51-R506) was used as the immunogen for the HBP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HBP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HBP1

Antigène: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Autre désignation: HBP1

Sujet: HBP1 antibody detects HMG-box transcription factor 1, a transcriptional repressor that modulates cell cycle progression, differentiation, and Wnt signaling. Encoded by the HBP1 gene on chromosome 7q22.3, this protein belongs to the high mobility group (HMG) family of DNA-binding transcription factors. HBP1 acts as a nuclear regulator that represses proliferation-associated genes, integrating signals from growth factors, oncogenes, and stress pathways to maintain cellular homeostasis and differentiation potential.

Structurally, HBP1 is a 513-amino-acid nuclear protein of approximately 60 kilodaltons containing an HMG-box DNA-binding domain and transcriptional repression domains that interact with histone deacetylases (HDACs) and chromatin remodeling complexes. These interactions enable HBP1 to repress genes such as CCND1 (Cyclin D1) and N-MYC, thereby inhibiting uncontrolled cell proliferation. HBP1 also contains regulatory phosphorylation sites that control nuclear localization and DNA-binding affinity in response to extracellular cues.

The HBP1 antibody is widely used in cell cycle, cancer, and transcription research to study gene repression, differentiation, and tumor suppression mechanisms. Western blot analysis detects a 60 kilodalton band corresponding to HBP1, while immunofluorescence shows strong nuclear localization in epithelial and neuronal cells. This antibody enables detailed examination of transcriptional networks controlling growth arrest and lineage commitment.

Functionally, HBP1 suppresses oncogenic transformation by inhibiting Wnt/beta-catenin signaling and antagonizing MYC-dependent transcription. It also promotes senescence and apoptosis in response to DNA damage and oxidative stress, acting as a barrier to tumorigenesis. Reduced HBP1 expression or mutation is associated with breast, lung, and colon cancers, where loss of repression contributes to hyperproliferation. Beyond cancer, HBP1 regulates differentiation programs in neurons, adipocytes, and muscle cells by coordinating chromatin remodeling and transcriptional silencing. The HBP1 antibody provides a valuable tool for exploring these pathways and assessing transcriptional regulation in normal and diseased tissues. NSJ Bioreagents validates this antibody for its applications, ensuring specificity and consistency in transcriptional research applications.

UniProt: O60381