HAAO anticorps (AA 52-286)

N° du produit ABIN7875557

Cet anticorps Lapin Polyclonal détecte spécifiquement HAAO dans WB, ELISA et IF. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour HAAO anticorps (AA 52-286) (ABIN7875557)

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAAO est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-HAAO anticorps

Épitope: AA 52-286

Fonction: HAAO Antibody / 3-hydroxyanthranilate 3, 4-dioxygenase / 3HAO

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived human recombinant protein (amino acids E52-G286) was used as the immunogen for the HAAO antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HAAO antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HAAO Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HAAO

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Autre désignation: HAAO

Sujet: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

UniProt: P46952