ASXL1 anticorps (AA 521-549)

N° du produit ABIN7875580

Cet anticorps anti-ASXL1 Polyclonal Lapin (ABIN7875580) détecte spécifiquement ASXL1 dans WB, FACS, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour ASXL1 anticorps (AA 521-549) (ABIN7875580)

Antigène: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASXL1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ASXL1 anticorps

Épitope: AA 521-549

Fonction: Additional sex combs-like protein 1 Antibody / ASXL1

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 521-549 from the human protein was used as the immunogen for the Additional sex combs-like protein 1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Additional sex combs-like protein 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Additional sex combs-like protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ASXL1

Antigène: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Autre désignation: Additional sex combs-like protein 1

Sujet: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

UniProt: Q8IXJ9

Pathways: Retinoic Acid Receptor Signaling Pathway