GSTK1 anticorps (AA 53-213)

N° du produit ABIN7875591

L’anticorps anti-GSTK1 Polyclonal Lapin est utilisé pour la détection de GSTK1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, ELISA, IP, FACS et IF.

Aperçu rapide pour GSTK1 anticorps (AA 53-213) (ABIN7875591)

Antigène: GSTK1 (Glutathione S-Transferase kappa 1 (GSTK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSTK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-GSTK1 anticorps

Épitope: AA 53-213

Fonction: GSTK1 Antibody / Glutathione S-transferase kappa 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human GSTK1 recombinant protein (Position: N53-K213) was used as the immunogen for the GSTK1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GSTK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GSTK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GSTK1

Antigène: GSTK1 (Glutathione S-Transferase kappa 1 (GSTK1))

Autre désignation: GSTK1

Sujet: GSTK1 antibody detects Glutathione S-transferase kappa 1, a mitochondrial and peroxisomal enzyme that catalyzes the conjugation of glutathione to reactive electrophilic compounds for detoxification and redox regulation. The UniProt recommended name is Glutathione S-transferase kappa 1 (GSTK1). This enzyme belongs to the kappa class of glutathione S-transferases, distinct from the cytosolic and microsomal families by its localization and substrate specificity.

Functionally, GSTK1 antibody identifies a 226-amino-acid enzyme that forms homodimers with catalytic sites capable of binding glutathione and a broad range of electrophilic substrates. GSTK1 participates in lipid peroxidation repair, oxidative stress defense, and metabolic detoxification within mitochondria and peroxisomes. It also contributes to cellular protection against reactive oxygen species and lipid-derived aldehydes.

The GSTK1 gene is located on chromosome 7q34 and is expressed in liver, kidney, and adipose tissue, with additional expression in metabolically active organs. GSTK1 is involved in maintaining mitochondrial redox balance and may influence energy metabolism and apoptotic signaling under oxidative stress conditions.

Pathologically, altered GSTK1 expression has been associated with obesity, diabetes, and cancer. Reduced GSTK1 levels compromise antioxidant defense, while overexpression may enhance cellular detoxification capacity. Research using GSTK1 antibody supports studies in oxidative stress, metabolism, and mitochondrial function.

GSTK1 antibody is used in western blotting, immunohistochemistry, and enzyme assays to detect glutathione S-transferases in subcellular compartments. NSJ Bioreagents provides GSTK1 antibody reagents optimized for research in redox biology, metabolism, and cellular detoxification.

Structurally, Glutathione S-transferase kappa 1 contains a thioredoxin-like fold and a conserved GSH-binding domain typical of GSTs, but features unique peroxisomal targeting signals. This antibody enables detailed analysis of GSTK1's enzymatic function and role in cellular defense mechanisms.

UniProt: Q9Y2Q3