TUSC1 anticorps (AA 54-209)

N° du produit ABIN7875647

Cet anticorps Lapin Polyclonal détecte spécifiquement TUSC1 dans WB, ELISA et IP. Il présente une réactivité avec des échantillons de Souris, Humain et Rat.

Aperçu rapide pour TUSC1 anticorps (AA 54-209) (ABIN7875647)

Antigène: TUSC1 (Tumor Suppressor Candidate 1 (TUSC1))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TUSC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-TUSC1 anticorps

Épitope: AA 54-209

Fonction: TUSC1 Antibody / Tumor suppressor candidate 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TUSC1 recombinant protein (Position: A54-L209) was used as the immunogen for the TUSC1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TUSC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TUSC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TUSC1

Antigène: TUSC1 (Tumor Suppressor Candidate 1 (TUSC1))

Autre désignation: TUSC1

Sujet: TUSC1 antibody detects Tumor suppressor candidate 1, encoded by the TUSC1 gene on chromosome 9p21. TUSC1 antibody is widely used to study this protein, originally identified in lung cancer research as part of a genomic region frequently deleted in tumors. Although not fully characterized biochemically, TUSC1 is strongly implicated as a tumor suppressor, participating in cell cycle regulation, apoptosis, and maintenance of genomic stability. Its expression pattern across tissues and frequent inactivation in cancers highlight its importance in normal growth control and oncogenesis.

Structurally, TUSC1 encodes a small cytoplasmic and nuclear protein with predicted coiled-coil regions that may serve as scaffolding modules. These domains suggest potential roles in mediating protein-protein interactions and stabilizing regulatory complexes. Despite lacking enzymatic motifs, TUSC1 likely influences signaling pathways indirectly by modulating the activity of other proteins or transcriptional regulators. Subcellular fractionation studies show that TUSC1 can shuttle between the nucleus and cytoplasm, further broadening its regulatory potential.

Functionally, TUSC1 acts as a negative regulator of cell growth. Studies demonstrate that cells lacking TUSC1 exhibit increased proliferation, while reintroduction suppresses colony formation in vitro and tumor growth in xenograft models. TUSC1 has been associated with activation of apoptotic pathways, possibly by facilitating mitochondrial apoptotic signaling and caspase activation. Its ability to influence both cell cycle and apoptosis highlights its tumor suppressor characteristics. Researchers use TUSC1 antibody to investigate expression changes between normal and malignant tissues, particularly in lung, ovarian, renal, and brain cancers.

Clinically, deletions or reduced expression of TUSC1 are observed in non-small cell lung carcinoma and multiple other tumors. Mechanistically, loss of TUSC1 often occurs through chromosomal deletion of 9p21, a locus that also contains CDKN2A, another tumor suppressor gene. Epigenetic silencing via promoter hypermethylation has been reported, adding another layer of regulation. Clinical studies suggest that TUSC1 status may correlate with prognosis, with low expression linked to more aggressive tumor phenotypes. Restoration of TUSC1 in cancer cell models increases sensitivity to chemotherapy and radiation, highlighting its therapeutic potential.

Beyond oncology, TUSC1 may also influence development and tissue homeostasis. Animal studies show tissue-specific expression during embryogenesis, suggesting developmental roles that remain underexplored. Transcriptomic data indicate potential involvement in neuronal pathways, though further research is needed. These diverse associations make TUSC1 an appealing target for continued study. NSJ Bioreagents supplies TUSC1 antibody as a reliable reagent for cancer research, molecular biology, and developmental studies.

UniProt: Q2TAM9