OLR1 anticorps (AA 55-363)

N° du produit ABIN7875688

Cet anticorps anti-OLR1 Polyclonal Lapin (ABIN7875688) détecte spécifiquement OLR1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour OLR1 anticorps (AA 55-363) (ABIN7875688)

Antigène: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OLR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-OLR1 anticorps

Épitope: AA 55-363

Fonction: Olr1 Antibody / Lox-1

Purification: Affinity purified

Immunogène: Recombinant mouse protein (amino acids Q55-I363) was used as the immunogen for the Olr1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Olr1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Olr1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur OLR1

Antigène: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Autre désignation: Olr1

Sujet: OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL). This gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression, however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease. LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.

UniProt: Q9EQ09