GLOD4 anticorps (AA 57-313)

N° du produit ABIN7875804

L’anticorps anti-GLOD4 Polyclonal Lapin est utilisé pour la détection de GLOD4 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour GLOD4 anticorps (AA 57-313) (ABIN7875804)

Antigène: GLOD4 (Glyoxalase Domain Containing 4 (GLOD4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLOD4 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-GLOD4 anticorps

Épitope: AA 57-313

Fonction: GLOD4 Antibody / Glyoxalase domain-containing protein 4

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human GLOD4 recombinant protein (Position: E57-G313) was used as the immunogen for the GLOD4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GLOD4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GLOD4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GLOD4

Antigène: GLOD4 (Glyoxalase Domain Containing 4 (GLOD4))

Autre désignation: GLOD4

Sujet: GLOD4 antibody detects Glyoxalase domain-containing protein 4, encoded by the GLOD4 gene on chromosome 17q25.3. GLOD4 antibody is widely applied in metabolism, detoxification, and mitochondrial biology research. Although GLOD4's precise enzymatic role remains incompletely defined, it contains homology to glyoxalase enzymes, which detoxify reactive dicarbonyls such as methylglyoxal, a byproduct of glycolysis.

Structurally, GLOD4 is a ~36 kDa protein with a glyoxalase-like fold. It is predicted to bind metal ions that assist catalysis, though definitive enzymatic activity has yet to be confirmed. Localization studies suggest enrichment in mitochondria, highlighting a role in redox balance and metabolic regulation.

Functionally, GLOD4 may protect cells from glycation stress by metabolizing reactive aldehydes. Its expression is broad, with higher levels in metabolic tissues such as liver, kidney, and muscle. Researchers use GLOD4 antibody to study mitochondrial metabolism, detoxification pathways, and oxidative stress responses.

Clinically, altered GLOD4 expression has been observed in cancer and metabolic disease. By influencing redox balance, GLOD4 may contribute to tumor survival under stress conditions. It is under investigation as a metabolic biomarker and therapeutic target. NSJ Bioreagents provides GLOD4 antibody for metabolic, mitochondrial, and cancer research.

Experimentally, GLOD4 antibody is applied in western blotting to detect the ~36 kDa protein, in immunofluorescence microscopy to study mitochondrial localization, and in immunohistochemistry to assess expression across tissues. Functional studies combining GLOD4 antibody with metabolic assays help clarify its enzymatic role in glyoxalase pathways.

UniProt: Q9HC38