TFF1 anticorps (AA 57-84)

N° du produit ABIN7875814

Cet anticorps anti-TFF1 Monoclonal Souris (Clone SPM573) (ABIN7875814) détecte spécifiquement TFF1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TFF1 anticorps (AA 57-84) (ABIN7875814)

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFF1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM573

Détail du produit anti-TFF1 anticorps

Épitope: AA 57-84

Fonction: pS2 Antibody / TFF1

Séquence: CFDDTVRGVP WCFYPNTIDV PPEEECEF

Purification: Protein G affinity chromatography

Immunogène: Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein were used as the immunogen for this pS2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The optimal dilution of the pS2 antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the pS2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TFF1

Antigène: TFF1 (Trefoil Factor 1 (TFF1))

Autre désignation: pS2

Sujet: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. It is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

UniProt: P04155

Pathways: EGFR Signaling Pathway