FTH1 anticorps (AA 58-180)

N° du produit ABIN7875839

Cet anticorps Souris Monoclonal détecte spécifiquement FTH1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FTH1 anticorps (AA 58-180) (ABIN7875839)

Antigène: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FTH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: FTH-2081

Détail du produit anti-FTH1 anticorps

Épitope: AA 58-180

Fonction: FTH1 Antibody / Ferritin heavy chain (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A human recombinant partial protein (amino acids 58-180) were used as the immunogen for the FTH1 antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the FTH1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the FTH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur FTH1

Antigène: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Autre désignation: FTH1

Sujet: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis