Recombinant Ferritin anticorps (Heavy Chain)

N° du produit ABIN7875842

Cet anticorps Lapin Monoclonal détecte spécifiquement Ferritin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Ferritin anticorps (Heavy Chain) (ABIN7875842)

Antigène: Ferritin (FE)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Ferritin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FTH-8700R

Détail du produit anti-Ferritin anticorps

Épitope: AA 58-180, Heavy Chain

Fonction: Recombinant Ferritin Heavy Chain Antibody / FTH1

Purification: Protein A/G affinity

Immunogène: A recombinant human FTH1 protein fragment (within amino acids 58-180) was used as the immunogen for the recombinant Ferritin Heavy Chain antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Ferritin Heavy Chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant Ferritin Heavy Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Ferritin

Antigène: Ferritin (FE)

Autre désignation: Ferritin

Sujet: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis