PREX2 anticorps (AA 582-1094)

N° du produit ABIN7875864

L’anticorps anti-PREX2 Polyclonal Lapin est utilisé pour la détection de PREX2 dans des échantillons de Humain et Souris. Il a été validé pour ELISA et WB.

Aperçu rapide pour PREX2 anticorps (AA 582-1094) (ABIN7875864)

Antigène: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PREX2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-PREX2 anticorps

Épitope: AA 582-1094

Fonction: PREX2 Antibody / DEPDC2

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids D582-Q1094) was used as the immunogen for the PREX2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PREX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PREX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PREX2

Antigène: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Autre désignation: PREX2

Sujet: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, also called DEPDC2 (DEP domain-containing protein 2), is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.

UniProt: Q70Z35