NUMB anticorps (AA 59-567)

N° du produit ABIN7875909

L’anticorps anti-NUMB Polyclonal Lapin est utilisé pour la détection de NUMB dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour NUMB anticorps (AA 59-567) (ABIN7875909)

Antigène: NUMB (Numb Homolog (NUMB))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUMB est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-NUMB anticorps

Épitope: AA 59-567

Fonction: NUMB Antibody

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids E59-A567) was used as the immunogen for the NUMB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NUMB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NUMB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NUMB

Antigène: NUMB (Numb Homolog (NUMB))

Autre désignation: NUMB

Sujet: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Whati 1/2s more, the numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

UniProt: P49757

Pathways: Cell-Cell Junction Organization