Calpain 3 anticorps (AA 603-632)

N° du produit ABIN7876071

L’anticorps anti-Calpain 3 Polyclonal Lapin est utilisé pour la détection de Calpain 3 dans des échantillons de Humain. Il a été validé pour WB, FACS et IHC (p).

Aperçu rapide pour Calpain 3 anticorps (AA 603-632) (ABIN7876071)

Antigène: Calpain 3 (CAPN3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calpain 3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Calpain 3 anticorps

Épitope: AA 603-632

Fonction: CAPN3 Antibody / Calpain 3

Immunogène: A portion of amino acids 603-632 from the human protein was used as the immunogen for this CAPN3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the CAPN3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4oC for up to one month. For long term, aliquot the CAPN3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Calpain 3

Antigène: Calpain 3 (CAPN3)

Autre désignation: CAPN3

Sujet: Calpain 3 is a member of the calpain family of proteases, which are enzymes that break down proteins in the body. Unlike other calpain enzymes that are present in various tissues, Calpain 3 is predominantly found in skeletal muscle. Its main function is to regulate the turnover of muscle proteins, ensuring that they are properly maintained and repaired. One of the key roles of Calpain 3 is to maintain the structural integrity of muscle fibers. It is involved in the breakdown of damaged or misfolded proteins, preventing them from accumulating and causing muscle dysfunction. Additionally, Calpain 3 plays a vital role in muscle regeneration, helping to repair damaged fibers and promote muscle growth. Deficiencies in Calpain 3 have been linked to various muscle disorders, including limb-girdle muscular dystrophy type 2A. In individuals with this condition, mutations in the CAPN3 gene lead to impaired muscle function and weakness.

UniProt: P20807

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development