TFEB anticorps (AA 68-350)

N° du produit ABIN7876399

Cet anticorps anti-TFEB Polyclonal Lapin (ABIN7876399) détecte spécifiquement TFEB dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TFEB anticorps (AA 68-350) (ABIN7876399)

Antigène: TFEB (Transcription Factor EB (TFEB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFEB est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TFEB anticorps

Épitope: AA 68-350

Fonction: TFEB Antibody / Transcription Factor EB

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids E68-L350) was used as the immunogen for the TFEB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TFEB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TFEB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TFEB

Antigène: TFEB (Transcription Factor EB (TFEB))

Autre désignation: TFEB

Sujet: Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm to the nucleus, resulting in the activation of its target genes. TFEB overexpression in cultured cells induces lysosomal biogenesis, exocytosis and autophagy. Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington, Parkinson and Alzheimer diseases, resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes. TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease. TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals.

UniProt: P19484