GANAB anticorps (AA 68-944)

N° du produit ABIN7876407

L’anticorps anti-GANAB Polyclonal Lapin est utilisé pour la détection de GANAB dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, ELISA, IF, ICC et FACS.

Aperçu rapide pour GANAB anticorps (AA 68-944) (ABIN7876407)

Antigène: GANAB (Glucosidase, Alpha, Neutral AB (GANAB))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GANAB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-GANAB anticorps

Épitope: AA 68-944

Fonction: GANAB Antibody / Neutral alpha-glucosidase AB

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human GANAB recombinant protein (Position: Q68-R944) was used as the immunogen for the GANAB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GANAB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GANAB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GANAB

Antigène: GANAB (Glucosidase, Alpha, Neutral AB (GANAB))

Autre désignation: GANAB

Sujet: GANAB antibody detects Neutral alpha-glucosidase AB, encoded by the GANAB gene. Neutral alpha-glucosidase AB is a catalytic subunit of the glucosidase II complex located in the endoplasmic reticulum. GANAB antibody provides researchers with a key reagent for studying N-linked glycoprotein processing, protein folding quality control, and disease pathogenesis related to glycosylation.

Neutral alpha-glucosidase AB catalyzes the sequential trimming of glucose residues from the N-linked glycan precursor Glc3Man9GlcNAc2 attached to newly synthesized glycoproteins. Research using GANAB antibody has shown that this activity is critical for proper folding of nascent glycoproteins and for quality control checkpoints that monitor protein maturation in the endoplasmic reticulum. Without glucosidase II activity, glycoproteins fail to fold correctly and are targeted for degradation.

Studies with GANAB antibody have revealed that mutations in GANAB cause autosomal dominant polycystic liver disease and polycystic kidney disease. These disorders result from disrupted glycoprotein maturation, impairing the function of proteins such as polycystin-1 and polycystin-2. The clinical connection between GANAB and polycystic disease emphasizes the physiological importance of glycan processing.

Dysregulation of Neutral alpha-glucosidase AB has also been linked to cancer and metabolic disease. Research using GANAB antibody has shown that altered glycosylation patterns in tumors are associated with progression, immune evasion, and metastasis. Because GANAB regulates a key early step in N-glycan processing, its activity influences global glycoprotein structure and function, making it a central regulator of cell biology.

GANAB antibody is widely applied in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting quantifies protein expression in cells and tissues, immunohistochemistry demonstrates localization within the endoplasmic reticulum, and activity assays confirm catalytic function in glycan trimming. These applications make GANAB antibody indispensable for glycobiology research.

By providing validated GANAB antibody reagents, NSJ Bioreagents supports studies into protein quality control, glycosylation, and disease. Detection of Neutral alpha-glucosidase AB provides researchers with insight into how glycan processing enzymes regulate proteostasis and pathology.

UniProt: Q14697