CD276 anticorps (AA 7-3)

N° du produit ABIN7876479

L’anticorps anti-CD276 Monoclonal Souris est utilisé pour la détection de CD276 dans des échantillons de Humain. Il a été validé pour WB, IHC (p) et ICC.

Aperçu rapide pour CD276 anticorps (AA 7-3) (ABIN7876479)

Antigène: CD276

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD276 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: 2009CT652-35-9

Détail du produit anti-CD276 anticorps

Épitope: AA 7-3

Fonction: B7-H3 Antibody / CD276

Purification: Protein G affinity

Immunogène: Recombinant human protein was used as the immunogen for the B7-H3 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the B7-H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD276

Antigène: CD276

Autre désignation: B7-H3

Sujet: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints