Tumor Suppressor ARF (CDKN2A) (AA 72-101) anticorps

N° du produit ABIN7876617

L’anticorps anti-Tumor Suppressor ARF Polyclonal Lapin est utilisé pour la détection de Tumor Suppressor ARF dans des échantillons de Humain. Il a été validé pour IHC (p), FACS et WB.

Aperçu rapide pour Tumor Suppressor ARF (CDKN2A) (AA 72-101) anticorps (ABIN7876617)

Antigène: Tumor Suppressor ARF (CDKN2A)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Western Blotting (WB)

Détail du produit

Épitope: AA 72-101

Fonction: Tumor suppressor ARF Antibody / CDKN2A / MLM

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 72-101 from the human protein was used as the immunogen for the Tumor suppressor ARF antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Tumor suppressor ARF antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Tumor suppressor ARF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détail du antigène

Antigène: Tumor Suppressor ARF (CDKN2A)

Autre désignation: Tumor suppressor ARF

Sujet: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

UniProt: Q8N726