TRIP6 anticorps (AA 8-476)

N° du produit ABIN7876835

Cet anticorps Lapin Polyclonal détecte spécifiquement TRIP6 dans WB, ELISA, IP et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TRIP6 anticorps (AA 8-476) (ABIN7876835)

Antigène: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIP6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Détail du produit anti-TRIP6 anticorps

Épitope: AA 8-476

Fonction: TRIP6 Antibody / Thyroid receptor-interacting protein 6

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TRIP6 recombinant protein (Position: P8-C476) was used as the immunogen for the TRIP6 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TRIP6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TRIP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TRIP6

Antigène: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Autre désignation: TRIP6

Sujet: TRIP6 antibody detects Thyroid receptor-interacting protein 6, a LIM domain-containing adaptor protein that links cell adhesion and cytoskeletal structures to signal transduction and transcriptional regulation. TRIP6 is part of the zyxin family of focal adhesion proteins and regulates cell motility, survival, and mechanical signaling. The TRIP6 antibody is widely used in cell signaling, cytoskeletal, and cancer biology to study focal adhesion dynamics and transcriptional control.

TRIP6 is encoded by the TRIP6 gene located on human chromosome 7q22.1. The protein is approximately 476 amino acids long and contains three LIM domains that mediate interactions with actin-associated proteins, kinases, and transcriptional regulators. TRIP6 localizes to focal adhesions, the cytoplasm, and the nucleus, reflecting its multifunctional role in signaling and structural regulation.

The TRIP6 antibody detects a 50 kilodalton band by western blot and shows strong focal adhesion staining under immunofluorescence. TRIP6 interacts with proteins such as paxillin, LPP, and integrin-linked kinase to regulate actin remodeling and cell migration. It also functions as a coactivator of transcription factors, including NF-kappaB and AP-1, linking mechanical and inflammatory signaling pathways.

In cancer, TRIP6 is frequently overexpressed and contributes to tumor cell migration, invasion, and survival. It mediates integrin and growth factor signaling, promoting metastasis through focal adhesion turnover and epithelial-to-mesenchymal transition. Conversely, in certain cell types, TRIP6 may act as a negative regulator of apoptosis and inflammation, demonstrating context-dependent roles.

As a versatile adaptor integrating cytoskeletal and transcriptional functions, TRIP6 is an important regulator of cellular mechanics and gene expression. NSJ Bioreagents provides a validated TRIP6 antibody optimized for its applications, supporting research into cell migration, mechanotransduction, and cancer progression.

UniProt: Q15654

Pathways: Cell-Cell Junction Organization