KPNB1 anticorps (AA 8-876)

N° du produit ABIN7876847

Cet anticorps Souris Monoclonal détecte spécifiquement KPNB1 dans WB, FACS, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour KPNB1 anticorps (AA 8-876) (ABIN7876847)

Antigène: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KPNB1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3I11F2

Détail du produit anti-KPNB1 anticorps

Épitope: AA 8-876

Fonction: KPNB1 Antibody / Importin subunit beta 1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids E8-A876) was used as the immunogen for the KPNB1 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the KPNB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the KPNB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur KPNB1

Antigène: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Autre désignation: KPNB1

Sujet: Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14974

Pathways: Protein targeting to Nucleus