NYAP2 anticorps (AA 83-617)

N° du produit ABIN7876946

Cet anticorps Lapin Polyclonal détecte spécifiquement NYAP2 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour NYAP2 anticorps (AA 83-617) (ABIN7876946)

Antigène: NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 (NYAP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NYAP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-NYAP2 anticorps

Épitope: AA 83-617

Fonction: NYAP2 Antibody / Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NYAP2 recombinant protein (Position: H83-L617) was used as the immunogen for the NYAP2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NYAP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NYAP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NYAP2

Antigène: NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 (NYAP2))

Autre désignation: NYAP2

Sujet: NYAP2 antibody detects Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2, a brain-specific signaling adaptor protein involved in neuronal morphogenesis, axon guidance, and synaptic plasticity. The UniProt recommended name is Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2). This protein functions as a cytoplasmic adaptor linking guidance cues to the activation of PI3K pathways that regulate actin dynamics and neurite outgrowth.

Functionally, NYAP2 antibody identifies a 1,228-amino-acid neuronal protein that interacts with IRSp53 and PI3K subunits to transmit signals from axon guidance receptors such as neuregulin and contactin-associated proteins. NYAP2 participates in a signaling cascade involving Crk-associated substrate (CAS) and small GTPases Rac1 and Cdc42, controlling actin filament organization and neuronal polarity. It localizes to axons and growth cones, where it modulates cytoskeletal remodeling during neuronal wiring and plasticity.

The NYAP2 gene is located on chromosome 2q37.3 and is selectively expressed in brain regions including cortex, hippocampus, and cerebellum. Its expression peaks during neuronal differentiation and synapse formation, aligning with its role in neurodevelopment and synaptic function.

Pathologically, altered NYAP2 expression or mutation disrupts neuronal connectivity and has been associated with neurodevelopmental disorders such as autism spectrum disorder and intellectual disability. Dysregulation of NYAP2-mediated PI3K signaling may also contribute to synaptic dysfunction in neurodegenerative diseases. Research using NYAP2 antibody supports studies in neuronal signaling, actin cytoskeleton regulation, and brain development.

NYAP2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect neuronal adaptor proteins. NSJ Bioreagents provides NYAP2 antibody reagents optimized for studies in axon guidance, synaptic signaling, and cytoskeletal remodeling.

Structurally, Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 contains multiple proline-rich motifs, SH3-binding regions, and tyrosine phosphorylation sites that enable dynamic interactions with signaling complexes. Its modular design allows integration of membrane receptor signals with intracellular actin regulatory machinery. This antibody facilitates exploration of NYAP2's function in neuronal network formation and synaptic communication.

UniProt: Q9P242