MBNL1 anticorps (AA 89-388)

N° du produit ABIN7877057

Cet anticorps Lapin Polyclonal détecte spécifiquement MBNL1 dans WB, ELISA, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Singe.

Aperçu rapide pour MBNL1 anticorps (AA 89-388) (ABIN7877057)

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MBNL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MBNL1 anticorps

Épitope: AA 89-388

Fonction: Muscleblind-like 1 Antibody / MBNL1

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids Q89-M388) was used as the immunogen for the Muscleblind-like 1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Muscleblind-like 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Muscleblind-like 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MBNL1

Antigène: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Autre désignation: Muscleblind-like 1

Sujet: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization