SYNM anticorps (AA 93-1554)

N° du produit ABIN7877178

L’anticorps anti-SYNM Polyclonal Lapin est utilisé pour la détection de SYNM dans des échantillons de Humain et Souris. Il a été validé pour ELISA, WB et FACS.

Aperçu rapide pour SYNM anticorps (AA 93-1554) (ABIN7877178)

Antigène: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYNM est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-SYNM anticorps

Épitope: AA 93-1554

Fonction: SYNM Antibody / Synemin

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SYNM recombinant protein (Position: R93-D1554) was used as the immunogen for the SYNM antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SYNM antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SYNM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SYNM

Antigène: SYNM (Synemin, Intermediate Filament Protein (SYNM))

Autre désignation: SYNM

Sujet: The SYNM antibody targets Synemin, a large intermediate filament-associated protein encoded by the SYNM gene. Synemin belongs to the intermediate filament (IF) protein family and serves as a cytoskeletal crosslinker that connects desmin and vimentin filaments to cellular structures. Through these interactions, Synemin helps maintain cellular architecture, mechanical stability, and signaling dynamics. The SYNM antibody allows precise detection of Synemin to study cytoskeletal organization and mechanotransduction in muscle and non-muscle cells.

Synemin exists in multiple isoforms, including alpha and beta forms, which differ in size and tissue distribution. The alpha isoform is primarily expressed in striated muscle, while the beta isoform occurs in smooth muscle and non-muscle tissues such as astrocytes and hepatocytes. Both isoforms contain a conserved intermediate filamenti 1/2binding domain that mediates filament anchoring and a unique C-terminal tail that interacts with cytoskeletal and signaling proteins. The SYNM antibody detects these isoforms, enabling evaluation of Synemin expression across tissues and developmental stages.

Functionally, Synemin acts as a structural scaffold linking intermediate filaments to focal adhesions, costameres, and the plasma membrane. It binds to alpha-actinin, dystrophin, and protein kinase A regulatory subunits, integrating cytoskeletal mechanics with signal transduction. Loss or mutation of Synemin disrupts cell shape, elasticity, and contractility, emphasizing its role in maintaining structural integrity. Researchers employ the SYNM antibody to characterize these cytoskeletal connections and assess their impact on tissue strength and cellular signaling.

Synemin expression is prominent in cardiac and skeletal muscle, where it contributes to sarcomere alignment and force transmission. Dysregulation of Synemin may contribute to muscular dystrophies, cardiomyopathies, and other myopathic conditions. The SYNM antibody supports these investigations by providing a consistent and specific reagent for identifying Synemin in muscle biopsies, cultured myocytes, and tissue sections. Beyond muscle, Synemin has been implicated in glial and epithelial cell structure, suggesting roles in neurobiology and cancer progression.

Experimental applications of the SYNM antibody include western blotting, immunofluorescence, and immunohistochemistry. These assays reveal Synemin's filamentous distribution and dynamic rearrangement during cell migration or mechanical stress. NSJ Bioreagents supplies the SYNM antibody to facilitate ongoing research into cytoskeletal organization, signal transduction, and mechanobiology. Its reproducible specificity ensures reliable detection across experimental platforms, enabling detailed study of how Synemin contributes to cellular resilience, structure, and disease processes.

UniProt: O15061